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  • Conversation: Depression: 'Orphan' brain receptor may be to blame

    • March 6, 2018 11:28 AM GMT
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      Depression: 'Orphan' brain receptor may be to blame

      New research uncovers a brain receptor that could explain why some people experience major depressive disorder after a stressful event, while others do not.
      Recently, an increasing amount of studies have been focusing on the neurological causes of depression, which is a psychiatric condition affecting more than 16 million adults in the United States.
      Only a few months ago, one such study pointed out that depression originates in brain areas associated with memory and reward.
      And, just a few days ago, another study laid out an electrical brain map of depression that could predict who develops the condition.
      Now, researchers from The Scripps Research Institute (TSRI) in Jupiter, FL, may have uncovered a new drug target for the treatment of depression.
      Scienitsts led by Kirill Martemyanov, Ph.D. — co-chair of the TSRI Department of Neuroscience — focused on a brain receptor called GPR158 after they noticed that levels of the GPR158 protein were very high in people with depression.
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